Propargyl-PEG1-THP is a PROTAC linker based on monomethoxypolyethylene glycol (PEG1), with a molecular formula of C₁₀H₁₆O₃ and a molecular weight of 184.23. Its structure consists of a propargyl group connected to a PEG1 chain via an ether bond, with a tetrahydrofuran (THP) protecting group at the terminal end. The production process involves precise control of ethylene oxide ring-opening polymerization and alkylation reactions to ensure monodispersity (PDI ≈ 1.0) and high purity (≥98%). As a click chemistry reagent, it can couple with azide-containing molecules through copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is widely used in PROTAC molecule synthesis, drug carrier modification, and nanomaterial functionalization, supporting targeted protein degradation technology and biomedical research.