TFP-PEG2-TFP (CAS No. 1446282-27-4) is a bifunctional polyethylene glycol derivative with a structure consisting of two tetrafluorophenyl ester (TFP) groups connected by a diethylene glycol (PEG2) chain. Its molecular formula is C₂₀H₁₄F₈O₆, with a molecular weight of 502.31. It exhibits dual characteristics of a hydrophobic tetrafluorophenyl ring and a flexible PEG chain. The production process typically involves esterification, using tetrafluorophenol and chlorinated polyethylene glycol as raw materials, which are condensed under alkaline conditions. Strict control of reaction conditions is required to avoid by-products. This compound is widely used in the field of bioconjugation, such as protein modification, antibody-drug conjugate (ADC) development, and preparation of radiolabeled probes. Its TFP groups can efficiently react with amino groups of biomolecules to form stable amide bonds, significantly improving the water solubility and biocompatibility of target molecules.