Thiol-PEG8-alcohol (CAS No. 791620-96-7) is a PROTAC molecule linker based on octaethylene glycol (PEG8), featuring a linear chain structure with terminal thiol (-SH) and hydroxyl (-OH) groups. Its molecular formula is C₁₆H₃₄O₈S, and its molecular weight is 386.5. Produced through precise chemical modification, it uses PEG8 as the backbone, with active groups introduced at both ends to ensure high purity (≥98%) and batch stability. This product is primarily used in PROTAC technology to connect E3 ubiquitin ligase ligands with target protein ligands, enabling selective degradation of target proteins via the ubiquitin-proteasome system. It is widely applied in drug development and signal pathway research in fields such as cancer and neurodegenerative diseases.