Benzyl-PEG25-amine structure consists of a benzyl group connected to 25 ethylene glycol repeating units (PEG25) via ether bonds, with a primary amine group (-NH₂) at the terminal end. It combines the dual characteristics of hydrophobic benzyl and hydrophilic PEG chains. The production process employs controlled polymerization technology, precisely regulating the ring-opening polymerization of ethylene glycol monomers to ensure uniform chain length, followed by amination modification to introduce an active amino group. This product is primarily used in PROTAC molecule design as a bridge connecting E3 ubiquitin ligase ligands and target protein ligands, enabling selective degradation of target proteins via the ubiquitin-proteasome system. It holds significant application value in cancer targeted therapy and signal pathway research.