ENDO-BCN-PEG3-ACID (CAS No.: 1807501-82-1) is a bioconjugation reagent based on click chemistry. Its molecular structure consists of endo-bicyclo[6.1.0]nonyne (endo-BCN), triethylene glycol (PEG3), and a carboxylic acid group (-COOH). The PEG3 chain imparts excellent water solubility and biocompatibility while reducing immunogenicity. The BCN group can react with azides via copper-free catalytic click chemistry to form stable triazoles, offering high efficiency under mild conditions.
The production process involves precise control over the degree of PEG chain polymerization and the stereochemistry of the BCN group to ensure a product purity of ≥95%. The carboxylic acid group can be further modified via activated esters (e.g., NHS) to expand functionalization potential.
This reagent is widely used in constructing drug delivery systems, studying protein-protein interactions, and developing biosensors. It is particularly suitable for in vitro and in vivo experimental scenarios requiring high selectivity and biocompatibility.