THP-PEG10-t-butyl acetate is a PEG10 derivative containing a tetrahydrofuran ether (THP) protecting group and a t-butyl acetate terminal group. Its structure consists of a THP cyclic ether moiety connected to the PEG10 chain via an oxygen atom, with the chain terminated by t-butyl acetate. The molecular formula is C₃₀H₅₈O₁₃, and the molecular weight is approximately 626.77. The production process employs an ethylene oxide (EO) ring-opening polymerization method, initiated by KOH under nitrogen protection. Reaction temperature is strictly controlled between 120-125°C to avoid side reactions. The final product is obtained through degassing, neutralization, and purification to achieve high purity. This compound is commonly used in PROTAC molecule synthesis as a flexible linker or as a hydrophilic spacer in drug delivery systems. Its THP protecting group can be removed under acidic conditions, enabling precise release of functional molecules.