THP-PEG6-t butyl ester is a polyethylene glycol (PEG6) derivative containing a tetrahydrofuran (THP) protecting group and a t-butyl ester group. Its structure consists of a six-unit polyethylene glycol chain connecting the THP group and the t-butyl ester group. The THP group protects hydroxyl groups, while the t-butyl ester group protects carboxyl groups, forming a dual-protecting group design. The production process includes: first synthesizing the PEG6 chain, introducing the t-butyl ester group via esterification, and then incorporating the THP group into the molecule through a nucleophilic reaction. This product is primarily used in research fields such as peptide/protein modification, surface functionalization of nanomaterials, and construction of bio-probes. Targeted modification is achieved through selective deprotection, enhancing molecular water solubility and stability.