Fmoc-N-amido-PEG7-amine Product Description
**Product Structure**: Fmoc-N-amido-PEG7-amine consists of three components: Fmoc (9-fluorenylmethoxycarbonyl) as an amine-protecting group, connected to a PEG chain containing 7 ethylene glycol units via an amide bond, with a primary amine group at the terminal end. Its molecular formula is C₃₂H₄₅N₁O₁₁, and its molecular weight is 619.7. The PEG chain in its structure imparts excellent water solubility and biocompatibility, while the Fmoc group provides controllability for reaction sites.
**Production Process**: Synthesis requires multiple organic reactions, including introduction of the Fmoc protecting group, extension of the PEG chain, and terminal amination. Key steps involve peptide coupling reagents (such as DCC/HOBt) catalyzing amide bond formation, with strict control over reaction temperature, pH, and solvent system to avoid side reactions. The purified product achieves a purity of over 95% and should be stored after low-temperature drying.
**Application Scenarios**: As a critical linker for PROTAC technology, it is used to construct bifunctional molecules by connecting E3 ubiquitin ligase ligands with target protein ligands, enabling ubiquitination and degradation of target proteins. Additionally, in biosensors, drug delivery systems, and peptide modification, its PEG chain can extend molecular half-life, and the Fmoc group supports subsequent chemical modifications.