Benzyl-PEG18-THP is a PEG-based PROTAC linker composed of a benzyl group, 18 ethylene glycol repeating units, and a tetrahydrofuran ether group. It has a large molecular weight and exhibits good water solubility and biocompatibility. The production process employs high-purity chemical synthesis, with precise control over reaction conditions and purification steps to ensure a product purity of ≥98%, verified by quality control methods such as LC/MS and NMR. As a core component of PROTAC technology, it connects the E3 ubiquitin ligase ligand with the target protein ligand, utilizing the ubiquitin-proteasome system to achieve selective degradation of the target protein.