武汉博仁凯润药业有限公司
产品展厅
tert-Butyl methyl(5-oxopentyl)carba mate
  • 品牌:Boren
  • 产地:武汉
  • 型号:g/kg
  • 纯度:95
  • cas:1620280-47-8
  • 发布日期: 2020-09-09
  • 更新日期: 2026-06-02
产品详请
产地 武汉
货号
品牌 Boren
用途 新药研发
型号 BK03218
包装规格 g/kg
外观 淡黄色液体
CAS编号 1620280-47-8
纯度 95%
别名 tert-Butyl methyl(5-oxopentyl)carba mate
级别 医药级
重金属 ppm

This compound (CAS number: 1620280-47-8) belongs to the PROTAC linker class, with a molecular formula of C₁₁H₂₁NO₃ and a molecular weight of 215.29. Its structure consists of an N-methyl amino group protected by a tert-butyloxycarbonyl (Boc) group connected to a 5-oxopentyl group (—CH₂CH₂CH₂COCH₃) via an amide bond, forming a linear molecular backbone. The production process typically starts with 5-oxopentanal, undergoing nucleophilic addition with Boc-protected methylamine, followed by oxidation and purification steps. Strict temperature control (e.g., reaction at 0°C) is required to avoid side reactions. As a key component of PROTAC technology, this linker connects the target protein ligand and E3 ubiquitin ligase ligand through a flexible alkyl chain, promoting the formation of a ternary complex. It is widely used in the development of tumor-targeted protein degradation drugs and chemical biology research.

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