tert-Butyl methyl(5-oxopentyl)carba mate
- 发布日期: 2020-09-09
- 更新日期: 2026-06-02
产品详请
| 产地 |
武汉
|
| 货号 |
|
| 品牌 |
Boren
|
| 用途 |
新药研发
|
| 型号 |
BK03218
|
| 包装规格 |
g/kg
|
| 外观 |
淡黄色液体
|
| CAS编号 |
1620280-47-8
|
| 纯度 |
95%
|
| 别名 |
tert-Butyl methyl(5-oxopentyl)carba mate
|
| 级别 |
医药级
|
| 重金属 |
ppm
|
This compound (CAS number: 1620280-47-8) belongs to the PROTAC linker class, with a molecular formula of C₁₁H₂₁NO₃ and a molecular weight of 215.29. Its structure consists of an N-methyl amino group protected by a tert-butyloxycarbonyl (Boc) group connected to a 5-oxopentyl group (—CH₂CH₂CH₂COCH₃) via an amide bond, forming a linear molecular backbone. The production process typically starts with 5-oxopentanal, undergoing nucleophilic addition with Boc-protected methylamine, followed by oxidation and purification steps. Strict temperature control (e.g., reaction at 0°C) is required to avoid side reactions. As a key component of PROTAC technology, this linker connects the target protein ligand and E3 ubiquitin ligase ligand through a flexible alkyl chain, promoting the formation of a ternary complex. It is widely used in the development of tumor-targeted protein degradation drugs and chemical biology research.