Amino-ethyl-SS-PEG3-NHBoc is a degradable ADC linker containing 3 ethylene glycol units (PEG3), with a molecular formula of C₁₅H₃₂N₂O₅S₂ and a molecular weight of 384.55. Its structure consists of an aminoethyl group, a disulfide bond (SS), a PEG chain, and a Boc protecting group. The disulfide bond imparts reductive responsiveness, while the Boc group can be deprotected under acidic conditions to expose an active amine. The production process involves ethylene oxide polymerization for PEG synthesis, introduction of the disulfide bond, and protection of the amino terminus with Boc. Precise control of reaction conditions is required to ensure a purity of ≥95%. This linker is widely used in antibody-drug conjugate (ADC) synthesis, where it connects antibodies to cytotoxins to enable targeted delivery, holding significant research value in the field of tumor therapy.